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Consequently, simulations suggest that while doxorubicin redox metabolism impacts GSH metabolism, the concentrations required to illicit a toxic response, with either a single or extended exposure, reside outside that of the therapeutic dosing range

The enrolled patients suffered from peripheral mono- and polyneuropathies of various origins including entrapment, traumatic, toxic/alcoholic, diabetic, metabolic, idiopathic, vascular or infective aetiology

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