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Long R3 insulin-like growth factor-I (IGF-I) infusion stimulates organ growth but reduces plasma IGF-I, IGF-II and IGF binding protein concentrations in the Guinea pig
Cardiovascular/metabolic benefits: Some large studies found that GLP-1s reduce the risk of major cardiovascular events, and may improve fatty-liver disease and other metabolic markers
Historically, such behavioral complexity was viewed as a disqualifying feature for drug development, as CNS-acting agents were associated with unpredictable neuropsychiatric liability and high regulatory barriers ( 5.4 Translational lessons from abandoned appetite peptides The historical trajectory of appetite and behavioral peptides reveals a recurring pattern: early development efforts often failed due to inadequate control over exposure, insufficient combination strategies, or overly conservative interpretations of side effects
Xu 2021)
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