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The most common reason cause of the Jarisch-Herxheimer Reaction are taking high doses of antifungals or antibiotics, but the condition can also occur when rapid changes of diet cause large-scale die-off of gut microflora overgrowth (also see: SIBO Diet)

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Pediatr Crit Care Med 13(Suppl 1):S1S82 Kochanek PM, Jackson TC, Ferguson NM, Carlson SW, Simon DW, Brockman EC, Ji J, Bayir H, Poloyac SM, Wagner AK, Kline AE, Empey PE, Clark RS, Jackson EK, Dixon CE (2015) Emerging therapies in traumatic brain injury