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249 Nuclear STAT3-Y705 activates glycolysis and fatty acid oxidation (FAO) genes, while mitochondrial STAT3-S727 and acetylated STAT3-K685 impair oxidative phosphorylation by destabilizing electron transport chain (ETC) complexes, supporting leukemia stem cell dormancy and persistence

By inhibiting NNMT, it alters the balance of S-adenosylmethionine (SAM) and nicotinamide metabolism, affecting DNA methylation patterns and histone modifications

Theyre not a passing fad theyve been studied for decades, and were only now seeing broader consumer awareness and more refined formulations, said Lancer

The rules here are non-negotiable