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Averill-Bates DA
If the substance is no longer needed, enzymes such as diamine oxidase (DAO) in the intestine, tissue and blood, or histamine N-methyltransferase (HNMT) in the liver, bronchial mucosa and central nervous system ensure that it is broken down
This receptor architecture provides functional specificity within the central nervous system
A series of transporters primarily acting in the kidney is responsible for the control of UA in the blood 3 , with URAT1 (coded by SLC22A12) responsible for most kidney reabsorption into the blood and ABCG2 (or breast cancer resistance protein, BCRP) mainly involved in secretion into urine
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