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All patient samples were collected in accordance with the principles of the Declaration of Helsinki and with the approval of the Institutional Review Boards of Avicenne Hospital and DFCI

However, such newly formed blood vessels are leaky because of their discontinuous endothelium, along with the obstruction of lymphatic drainage, producing vascular hyperpermeability and enhanced permeation [41]

Alternate injection sites include the outer thigh or upper arm fatty tissue if rotating sites to prevent lipohypertrophy (tissue buildup from repeated injections)

Buglio D, Schober W, Contractor R, McQueen T, Zeng Z, Kantarjian H, Weiser MA, Andreeff M , Konopleva M