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Discovery of a novel series of orally bioavailable and CNS penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) non-competitive antagonists based on a 1,3-disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione core
Es indicador visual de complejo intacto: si la solucin se vuelve verde, incolora o turbia indica disociacin del cobre y prdida de actividad
Coker, Robert H., et al
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