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Like Mounjaro, it reduces caloric intake through GLP-1 and GIP receptor activation
In some patients, gastrointestinal side effects can be severe enough to lead to treatment discontinuation
Most people do fine, but some may experience mild digestive issues such as nausea or vomiting
Retatrutide's triple receptor activity produces larger total weight reduction in clinical trials (~24-29% vs ~20-22% for tirzepatide), but the side effect profile is more demanding during titration
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