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New England Journal of Medicine (2025) The REDEFINE 1 Phase 3 trial was a landmark 68-week, double-blind, randomized study comparing CagriSema (cagrilintide 2.4 mg plus semaglutide 2.4 mg) with semaglutide alone, cagrilintide alone, and placebo in 3,417 adults with obesity or overweight without diabetes
Additionally, the trials focused on specific outcomes like weight loss efficacy
Inntag design was initiated by a search for (small) protein domains of specific three-dimensional structure, with further filters applied computationally, followed by specific point modifications to arrive at several candidates
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