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Hence, in the spleens CD4 + FoxP3 + Tregs were increased, while proarthritic Th1 (CD4 + Tbet + ) and Th17 (CD4 + RORt + ) were decreased (Supplementary Fig

Evidence has demonstrated that iron deposition occurs in the brains of migraine patients ( Topiramate has been proposed as a migraine preventive medication because it inhibits ferroptosis via the glutathione peroxidase 4 (GPX4), GSH, and cystine/glutamate antiporter (System Xc-)

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Adiponectin also decreases hepatic de novo glucose production and reduces free fatty acid levels in the liver (196), thereby mitigating hepatic steatosis, enhancing insulin sensitivity, and improving the circulating lipid profile ( Figure 1 Section E)