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The ability of the placenta and fetus to synthesize carnitine suggests that in circumstances when maternal carnitine supply is limited, carnitine biosynthesis by the fetal-placental unit may supply sufficient carnitine for placental and fetal metabolism
However, the ominous octet as described by DeFronzo, suggests that multiple drugs targeting different metabolic abnormalities in type 2 diabetes are required to reduce subsequent morbidity and mortality [7]
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