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Improvements in biomarkers such as CSF p-tau, glial fibrillary acidic protein, and tau-PET indicate downstream effects, though these might reflect indirect responses to A removal.62 Persistent cognitive decline despite A clearance suggests contributions from tau pathology and other mechanisms, underscoring the need for multi-targeted treatment approaches.98 Interpretation of downstream biomarker changes remains complex
However, semaglutide and tirzepatide are not interchangeable
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