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The Lancet , 2025
GLP-1 drugs solve this by using receptor agonists (engineered molecules that bind to and activate the same receptor as the natural GLP-1 hormone) but are built to resist DPP-4 and stay active for much longer
These reactions were observed in clinical trials: Abdominal distension Abdominal pain Acute gallbladder disease Acute kidney injury Acute pancreatitis Allergic reactions Constipation Diarrhea Dizziness Dyspepsia (indigestion) Eructation (burping) Fatigue Flatulence Gastroenteritis Gastroesophageal reflux disease Headache Hypoglycemia (in diabetic patients) Nasopharyngitis (cold) Nausea Thyroid C-cell tumors Vomiting Studies, consumer reports and lawsuits have highlighted other side effects of semaglutide medications
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