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That's a big part of why daily oxidative stress has become one of the most-studied factors in longevity research
(6) L E Diamond, D C Earle, R C Rosen, et al (2004) Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction International Journal of Impotence Research, Volume 16, pages 5159 (2004)
Some individuals report that hunger feels more intense initially, though this likely represents return to baseline rather than true rebound hyperphagia
Walk after meals to stimulate bowel movements and try to establish a scheduled toilet time, preferably after breakfast
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