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This occurs because during significant caloric restriction, the liver secretes more cholesterol into bile whilst the gallbladder contracts less frequently, creating conditions favourable for stone formation
However, these limitations present opportunities for future research
The prerequisite for this, however, is that the body is supplied with enough macronutrients (carbohydrates, fats and proteins) for synthesis
Chou SH, Chamberland JP, Liu X, Matarese G, Gao C, Stefanakis R, et al
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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