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these AGEs then bind to RAGE receptors, activating NOX enzymes and generating O 2 - while triggering pro-inflammatory NF-B signaling (Yan et al., 2023)
The first patient was a 64-year-old man from Rio Grande do Sul, Brazil, who developed congestive heart failure with bilateral pulmonary infiltrates and pleural effusion on chest X-ray in June 2016
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They can also cause more serious bleeding problems, including internal bleeding, so you always want to be on the lookout for symptoms
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