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Unlike the formation of autophagosome in autophagy or nuclear fragmentation in apoptosis, ferroptosis is distinguished by diminished mitochondrial size, increased mitochondrial membrane density, reduced or absent mitochondrial cristae, destroyed mitochondrial outer membrane and normal nuclei
The consequences of this condition can be devastating and, in some cases, fatal
Glutathione reductase delivers one proton from the solution and the other from NADPH to the two sulfur atoms of glutathione disulfide (GSSG)
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