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Its receptor, GLP-1R, is a class B G-protein-coupled receptor
The same is true for peptides
For both of these final limitations, the use of rich multimodal clinical data such as clinical notes to assess patient-level features driving motivation for GLP-1 use and discontinuation, as well as imaging to quantify and assess fat loss through CT scans could help shed light on the true impact of GLP-1s on body composition as well as patient profiles that are related to varying levels of treatment effect
While some participants did stop treatment because of nausea or related symptoms, the overall discontinuation rates for retatrutide were not substantially higher than those for placebo
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