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If you live with digestive conditions such as Crohns disease, coeliac disease or IBS, or take medications like metformin or acid reflux tablets long term, your gut may struggle to absorb B12 no matter how well you eat
The dose is often very high, as most of it will pass through your digestive system and be excreted by your body
In adipose models, reduced NNMT activity has been linked with smaller adipocyte size and diminished fat depots, suggesting a potential role for this inhibitor in fat mass modulation under research conditions
But our natural NAD+ levels decline with age, impacting our skin health, energy levels, and risk of age-related disease
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