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Multiple clinical studies show EVOO increases postprandial GLP-1 and PYY (satiety hormones) while reducing ghrelin (the hunger hormone), through mechanisms that partially overlap with what GLP-1 drugs do pharmacologically
As the majority of L-cells are located in the distal ileum and colon, the early phase is likely explained by neural signalling, gut peptides or neurotransmitters
Larger individuals may achieve therapeutic concentrations at different rates than smaller individuals on identical doses
Importantly, the delayed gastric emptying has clinical implications for medication absorption
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