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Oral GLP-1 therapies emerged as game-changers: Rybelsus (oral semaglutide) was approved for diabetes in 2019, and in December 2025 the FDA approved Wegovys first oral pill (25 mg semaglutide) for obesity ( [35] )
In an exploratory analysis of CV risk factor changes in people with obesity but not T2D, aggregating data from STEP1 and STEP4 studies of the weight loss effects, a mean placebo-adjusted treatment effect of 5.1 mmHg for SBP and 2.4 mmHg for DPB was reported [17]
Do not drop back to a lower dose unless symptoms are severe
Baseline labs also help identify previously undiagnosed conditions such as prediabetes, thyroid dysfunction, early kidney disease, or elevated liver enzymes
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