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2 The immunotherapeutic landscape of osteosarcoma: challenges and resistance mechanisms 2.1 The immunosuppressive TME The osteosarcoma TME is a complex ecosystem comprising malignant cells, stromal cells, immune infiltrates, and ECM components embedded within a mineralized bone scaffold (9, 22)
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doi: 10.1006/nbdi.2002.0483 52 FarfelJ
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