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Supplementary material The Supplementary Material for this article can be found online at: Abbreviations GLP-1RA:glucagon-like peptide-1 receptor agonist,FDA:the adverse event reporting system of the U.S

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Synthetic semaglutide API is manufactured using solid-phase peptide synthesis (SPPS) technology with Fmoc chemistry, building the 31-amino acid peptide chain sequentially on a resin support before cleaving, purifying, and attaching the fatty acid side chain

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