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If your vial has been exposed to temperatures above 30 degrees Celsius for more than a few hours, assume significant potency loss
Two factors compound: drug exposure scales with body weight (lighter body = more drug per pound), and physiological response varies by metabolic and cardiovascular phenotype
Most patients begin noticing some weight loss within the first few weeks of starting a GLP-1 agonist, especially as the dose is gradually increased to the optimal maintenance level
comprehensive evaluations are included in Supplementary Figures S7 , S8
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