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Nevertheless, some barriers such as limited tumor cell uptake, low selectivity, poor tumor permeability, and low plasma stability need to be overcome

A 2021 review published in Clinical Pharmacology & Therapeutics noted that most therapeutic peptides undergo proteolytic degradation rather than CYP450-mediated metabolism, making formal hepatic impairment studies less common in peptide drug development [4]

Neither approved nor specifically prohibited by Health Canada, it remains available as a research chemical for laboratory investigation

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