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Early research suggests it has a promising safety record within these ranges

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Using structure-based analyses and cell models, including patient fibroblasts, of this variant, we found that the missense variant destabilized a critical loop, which disrupted the active site and caused a substantial loss of enzymatic function

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To maximize delivery and minimize systemic exposure, the researchers formulated TPZP into fibrin-targeting nanoparticles (FT11-TPZP-NPs)

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scientific studies support them

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