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The Advertising Standards Authority (ASA) has ruled against several weight-loss patches in recent years for unsubstantiated efficacy claims, including specific rulings in 2020, 2022 and 2023 on slimming patches that promised appetite suppression or fat-burning effects
Melanotan II is unregulated and illegal to sell, and various countries including Australia and the UK have issued warnings against the use of it
Simply put, GLP-1 agonists mimic this hormone, and contribute towards controlling blood sugar levels and reducing weight
50 However, two phase 3 trials of selonsertib (an ASK-1 inhibitor) were terminated early due to a lack of efficacy in MASH adults with stage 3 (NCT03053050) and stage 4 (NCT03053063) fibrosis
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