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Coverage of GLP-1s for weight loss has become particularly controversial: a 2025 ICER report noted only 18% of large employers cover these drugs ( [26] ), and 3052% of obesity-drug prescriptions were denied by payers as not covered ( [27] )
Butt, A
It makes a recommendation to FDA on whether each substance has, in its words, "a clinical need" that is not addressed by an approved drug, and whether the available evidence on safety, efficacy, and historical use supports listing
The fermentation process is not competitive with low-cost industrial chemical synthesis as yet
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