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Heart Disease Being overweight strains the heart, raises blood pressure, and increases cholesterol levels, leading to a higher risk of heart disease, heart attack, and stroke
Taking up to 2 g/day in 3 divided doses is recommended to avoid any side effects [11]
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Therefore, compounds 27 and 28 exhibited the most significant affinity for PDE1B among all the compounds, designating them as potential candidates for synthesis and preclinical assessment to evaluate their PDE1B inhibition and antipsychotic properties (Al-Nema et al., 2023)
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