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In CD4 T cells, extracellular lactate not only inhibits their migratory capacity, but also contributes to their conversion to a proinflammatory Th17 phenotype, characterized by increased expression of cytokines such as IL-2 and IL-17 [116, 117]

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This does not mean fragment synthesis is ineffective

FIGURE 3 PEROXIREDOXINTHIOREDOXIN REDOX CYCLE Peroxiredoxins constitute a family of thiol-specific peroxidases that rely on thioredoxins (Trxs) as the hydrogen donor for the reduction of H 2 O 2 and lipid hydroperoxides ( 2 O 2 produced by the mitochondrial respiratory chain