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Meta-analyses of randomised controlled trials (RCTs) also confirm that energy-restricted MD interventions yield greater weight loss than control or low-fat diets, particularly when combined with increased physical activity [116]
Although studies have demonstrated that GLP-1RAs can improve weight management, glucose control, and cardiovascular health, which are all risk factors associated with neurodegenerative diseases, the direct impact on preventing neurodegeneration is not yet fully understood
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