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They function as a hub for the exchange of essential metabolites, including lipids and calcium ions, between mitochondria and ER 3,4
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Some of the most important of these are short-chain fatty acids (SCFAs)
Louis, MO, USA), 50 mM Tris-HCl (pH 8.0), 75 mM NaCl, and a protease inhibitor cocktail (Roche, West Sussex, UK)
Because it is designed for extended activity relative to native amylin, cagrilintide is often discussed in research comparing duration of receptor engagement and downstream endocrine markers
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