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Under these conditions, eNOS changes the nitric oxide free radical to a superoxide anion due to reduced tetrahydrobiopterin (BH4) or L-arginine (L-Arg) levels [71]
Collectively, these data have identified a biological difference between children who are discordant for konzo and emphasize the role of oxidative stress in neglected motor system diseases, effectively opening new venues for research into potential disease mitigation strategies
ROS accumulation and the subsequent damage to lipids, proteins, and DNA highlight universal biochemical constraints that limit plant productivity
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