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GLP-1RAs appear to favor pro-survival responses in -cells, heart, brain and bone where the IGF-1/IGF-1R system appears to play an important role

Mechanism of Action: GHS-R1a Receptor Binding Requires Intact Peptide Structure Ipamorelin functions as a selective ghrelin mimetic, binding to growth hormone secretagogue receptor 1a (GHS-R1a) in anterior pituitary somatotrophs to stimulate pulsatile GH release without affecting prolactin or cortisol secretion

224 Although, there is evidence to suggest that islet alpha-cells can secrete GLP-1 during healthy circumstances and that this secretion becomes elevated during diabetic/disease conditions, whether these cells secrete GLP-1 and the physiological relevance of this remains unclear