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Conclusions To summarize, more than 19 years after exenatide's approval, newer once-weekly GLP-1 medicines like semaglutide and tirzepatide have shown long-term efficacy and safety for type 2 diabetes and obesity
The longer session allows for a steady, controlled infusion of larger fluid volumes
By doing so, they can hold on to as much muscle as they can and retain the muscle that theyve already got and hopefully the weight that they lose as a product of taking that kind of medication will be predominantly fat
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![Structure of [ 3 H]liraglutide (top) and the GLP-1 receptor agonists](https://www.researchgate.net/publication/45650716/figure/fig2/AS:667822585806848@1536232720030/Structure-of-3-Hliraglutide-top-and-the-GLP-1-receptor-agonists-liraglutide-and.png)
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