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The initial drop includes water weight and glycogen depletion

A PubMed search limited to clinical trial pubs found no results

Lab Store Retatrutide 10mg $160.00 Peptide: Retatrutide 10mg Type: Longevity Brand: Bio Stem (For research purposes only) Retatrutide is known as a triple agonist , meaning it activates: GLP-1 receptors helps control appetite + slows digestion GIP receptors improves insulin response + nutrient handling Glucagon receptors increases energy expenditure + fat burning Retatrutide is a multi-receptor agonist currently being studied for its interaction with metabolic pathways, including GLP-1, GIP, and glucagon receptors

This reduces total injection frequency and makes the protocol easier to maintain