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The dissolved solution should be clear blue from the copper-bound GHK-Cu
Meanwhile, the novel thermosensitive hydrogel SCC15 PLHCu@Gel loaded with disulfiram derivative CPD12C15 (SCC15) and tumor-targeted Cu + (PLHCu), can inhibit tumors by enhancing tumor-infiltrating cytotoxic CD8 + T cells, promoting DCs maturation, and suppressing Tregs and MDSCs (214)
Under hypoxia, mitochondrial electron transport chain (ETC) dysfunction at complexes I, II, and III generates superoxide radicals, which are amplified by coppers redox-cycling properties [115, 116]
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