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For PV3-SC8 GPP3+GSH and PV3-SC8 pleconaril+GSH particle picking was performed in an automated manner with crYOLO 41 using a neural network trained model generated from the apo PV3-SC8 dataset 33 , after which particle coordinates were saved and imported into RELION

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Similarly, changes in albuminuria appear as the strongest predictor of major kidney outcomes according to the Parameter Response Efficacy (PRE) score, an algorithm integrating several biomarkers of renal adverse events, as treatment with liraglutide resulted in a 16.2% estimated relative risk reduction (RRR) of kidney outcomes, similar to the observed RRR of 15.5%, which was mainly driven by UACR changes (RRR 13.2%) [15]