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In vitro studies, preclinical studies, retrospective studies and randomized clinical trials performed in Europe and the USA were included

Regular kidney function assessments are recommended, especially for those with pre-existing kidney disease

The importance of individualised, holistic treatment in the context of complex clinical decisions was also highlighted by the lack of consensus regarding use of SGLT2is versus GLP-1 RAs in frailty, with differing preferences depending on specific risks or symptoms, requiring clinical judgement to balance efficacy and safety

Factors that can impact your risk of a serious heart event include diabetes