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Mitochondrial dysfunction and oxidative stress constitute central mechanisms in MASH pathogenesis, with MASLD progression closely linked to mitochondrial impairment (69)

The UK medicines regulator, the MHRA, has updated the product information for healthcare professionals and patients regarding the "small risk of severe acute pancreatitis in patients taking GLP-1s." While rare, the sheer scale of GLP-1 use in the UK with one recent study suggesting 1.6 million adults had used them in the last 12 months, and 3.3 million were interested in trying them in the following year makes it important for clinicians and patients to be aware of the warning signs of pancreatitis, said the regulator

Long-term intake of a high protein diet modulates liver steatosis and fat accumulation in OVX mice

Cagrilintide is a synthetic, long-acting amylin analogue developed by Novo Nordisk