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Moreover, as the NLRP6 is an intracellular PRR, it is usually considered as a downstream of recognizing pathogen, that is, a mediator activated and stimulated the inflammation and host defense (Medzhitov, 2007
doi: 10.1210/jcem-41-6-1130 42 LiuYGongCLiJNingXZengPWangLet al
However, there was a time-dependent downregulation of plasm IGF-1 content in the rat models (Supplementary Fig
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