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Nutrients , 12 (5), 1389
The honest answer is: it depends entirely on the individual case
Adding pathways adds mechanisms: tirzepatide outperforms semaglutide because two pathways work better than one, and retatrutide may outperform tirzepatide because three pathways address both caloric intake (appetite) and caloric output (energy expenditure) simultaneously
In clinical trials, GLP-1s enhanced smoking cessation outcomes when paired with nicotine patches
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