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Our findings align with previous observational studies on GLP-1 RAs, which generally report no significant association between these medications and increased suicide risk ( The psychiatric safety observed in our study is consistent with findings from major RCTs involving tirzepatide, such as the SURMOUNT trials ( The reduction in suicidal ideation and attempts observed in patients treated with tirzepatide could be explained by several biological mechanisms
female=1251, 55.4%) from 64 countries completed the survey)
In the study cohort of the Omstead County, Minnesota, USA, from 2000 to 2010, the incidence of HF decreased from 3.1 cases per 1,000 people to 2.2 cases
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