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Circ Res 118:368370
FDA prescribing information for some GLP-1 receptor agonists (particularly those approved for weight management) includes recommendations to monitor heart rate at regular intervals and consider discontinuation for sustained increases in resting heart rate
Clinical trials have demonstrated the weight reducing effect continues at the same rate through 2.25 years of continued use
And here's where we bring in behavioral and physiologic evidence we know for decades, before these medications existed
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