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The 12mg arm produced the greatest mean weight reduction ( -24.2% at 48 weeks )
In their separate Phase 2 trials, retatrutide monotherapy showed larger weight loss (~24.2% at 48 weeks, 12 mg) than standalone cagrilintide (~10.8% at 26 weeks, 4.5 mg), and indirect network meta-analyses rank retatrutide highly
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Specifically, B12 in animals is essential for carbohydrate, fat and protein metabolism, and the formation and regeneration of red blood cells, as well as the maintenance of the central nervous system
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