While the beneficial effects of low IGF-1 action on aging seems well supported by data in model systems 6,7 and unique human populations 13,16 , a broader examination of the literature suggests that a more nuanced, complex, and controversial relationship exists between IGF-1, aging, and disease, which is indicative of the pleiotropic actions attributed to IGF-1 in cells and tissues 12,19
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A 2026 UK review of the October 2025 Neurology study linking high intake to ~62% faster cognitive decline, the aspartame methanol/phenylalanine/microglia neuroinflammation and BDNF/TrkB mechanism, the 2025 University of Colorado erythritol blood-brain-barrier and stroke study, the reverse-causation trap, the WHO/IARC verdict and the UK sugar-tax reformulation angle versus Dihexas unproven HGF/c-Met synaptogenesis, and why switching to water beats a peptide Read the full review NewNutrition, Metabolic & Cognitive Neuroscience 8 July 2026 Dihexa for Keto & Low-Carb Brain Fog: Ketones, the Keto Flu, BHB & the 2026 UK Review Does keto cause brain fog or clear it