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individual results vary Tirzepatide (Zepbound): In large clinical trials, average weight loss was meaningful over roughly 72 weeks when combined with lifestyle modifications

Couture Med Spa reports a similar pattern among its own tirzepatide and semaglutide patients, listing mild nausea or upset stomach, temporary irritation at the injection site, fatigue or headaches, and changes in appetite, and adds that most side effects fade as the body adjusts to treatment (couturemedspa.com)

However, there has been some debate about a possible connection between melanosis coli and colon cancer

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