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The mechanism for IFN-- and IL-17-associated disease pathogenesis includes their downstream effector chemokines, such as IFN--inducible protein of 10 kDa (IP-10 or CXCL10) and monokine-induced by IFN- (MIG or CXCL9) that upregulate matrix metalloproteinases (MMP)12 and MMP9 69
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