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IGF-1 can act over its putative receptor (IGF-1R) or it can also bind to the insulin receptor (IR), albeit with less affinity [9]
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However, other studies have indicated that POMC GLP-1R knockdown can increase HFD-induced weight gain, and ARC GLP-1R blockade by GLP-1R antagonists attenuated the anorexic effects of liraglutide [57]
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