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NF-kB: the transcription factor that controls everything If the IL-23/TH17 axis is the engine of psoriasis and TNF-alpha is the ignition switch, then NF-kB is the control room

Lifestyle modifications: Addressing modifiable risk factors is crucial and may improve erectile function independently or enhance response to medication: Weight loss in overweight or obese men Regular physical activity (150 minutes of moderate-intensity exercise weekly) Smoking cessation (smoking damages blood vessels and significantly worsens ED) Alcohol moderation (excessive alcohol impairs erectile function) Optimising management of diabetes, hypertension, and hyperlipidaemia Psychological interventions: Cognitive behavioural therapy (CBT) or psychosexual counselling may benefit men where psychological factors contribute to ED, particularly performance anxiety or relationship difficulties

FOR DRY SKIN SOURCE: NHS inform

Usually, these side effects get better over time